4F-MPH

Buy 4F-MPH online: High-Purity 4-Fluoromethylphenidate Research Chemical | Lab-Tested 99%

4F-MPH (4-Fluoromethylphenidate, also known as 4-FMPH or 4F-MPH research chemical) is a potent synthetic stimulant and close structural analog of methylphenidate (Ritalin®), specifically engineered for advanced neurochemical, pharmacological, forensic-toxicological, and analytical research. The addition of a fluorine atom at the para position of the phenyl ring creates a compound with distinct physicochemical and pharmacological properties compared to the parent methylphenidate molecule, including potentially enhanced lipophilicity, metabolic stability, dopamine transporter (DAT) selectivity, and altered pharmacokinetic profile.

4F-MPH is one of the most intensively studied fluorinated phenidate derivatives in contemporary research, valued as a high-affinity dopamine-norepinephrine reuptake inhibitor (DNRI) with minimal serotonergic activity. It serves as a critical reference standard and pharmacological tool in:

• Dopamine transporter (DAT) and norepinephrine transporter (NET) binding & release assays
• Structure-activity relationship (SAR) studies of ring-substituted methylphenidate analogs
• Comparative transporter pharmacology versus methylphenidate, ethylphenidate, 4F-EPH, and other fluorinated phenidates
• Forensic method development, validation, and metabolite identification in seized-drug and postmortem toxicology
• Locomotor activity, stereotypy, conditioned place preference, and behavioral sensitization models
• Analytical profiling of emerging novel psychoactive substances (NPS) and designer stimulants

Product Specifications – 4F-MPH for Sale

• Chemical Name: 4-Fluoromethylphenidate
• IUPAC Name: Methyl 2-(4-fluorophenyl)-2-(piperidin-2-yl)acetate
• CAS Number: 1354631-33-6
• Molecular Formula: C₁₄H₁₈FNO₂
• Molecular Weight: 251.30 g/mol
• Appearance: White to off-white fine crystalline powder
• Purity: ≥99% (third-party verified by HPLC, GC-MS, and ¹H-NMR)
• Form: Vacuum-sealed, tamper-evident packaging
• Solubility: Highly soluble in ethanol, methanol, DMSO; moderately soluble in acidified water/saline
• Storage: Cool (2–8 °C), dry, dark, airtight container – protect from light, heat, and moisture
• Shelf Life: Typically 2–3 years under recommended conditions

Why Laboratories & Researchers Choose Our High purity 4F-MPH Powder

• Independent third-party purity verification – every batch ships with current Certificate of Analysis (COA) showing HPLC, GC-MS, and NMR data
• Consistent batch-to-batch quality – critical for longitudinal studies, multi-site collaborations, and method validation
• Accurate net weight & no fillers – precise, reproducible dosing
• Superior handling characteristics – fine, non-static powder with excellent flow and solubility
• Secure, discreet global shipping – plain packaging, tracked delivery, chain-of-custody documentation available
• Competitive bulk & institutional pricing – tailored rates for universities, contract research organizations (CROs), forensic labs, and research consortia
• Research-use-only labeling & compliance support – clear documentation to support legitimate scientific intent

Typical 4F-MPH Dosage Ranges in Controlled Research (Reference Only)

4F-MPH dosage is highly context-dependent and determined by the specific experimental model:

• Analytical calibration & reference standard preparation: 0.05–5 mg (standard curves, quality control)
• In-vitro transporter assays (DAT/NET/SERT): 0.1 nM – 10 μM (most active window: 30–300 nM)
• Rodent locomotor activity & behavioral pharmacology: 0.3–10 mg/kg i.p. or s.c. (dose-response curves common)
• High-dose neurochemical, toxicity, or overdose modeling: 10–30 mg/kg (ethically restricted, IACUC-approved only)

Published 4F-MPH research predominantly utilizes the 1–10 mg/kg range in vivo and 10 nM – 3 μM concentrations in cellular/transporter assays, reflecting the compound’s significantly higher potency compared to methylphenidate (typically 3–5× more potent at DAT).

Safety & Handling Requirements by 4F-MPH research chemical supplier

4F-MPH is a potent monoamine-releasing agent and reuptake inhibitor and must be handled only under controlled laboratory conditions:

• Work exclusively in a certified Class II biological safety cabinet or fume hood
• Wear appropriate PPE: nitrile gloves, lab coat, safety goggles, and respiratory protection
• Prevent skin contact, inhalation, and aerosol generation
• Dispose of all waste as hazardous chemical material per institutional and local regulations
• Store in amber glass vials, sealed, at 2–8 °C, protected from light, heat, humidity, and air

4F-MPH side effects in research models are primarily related to excessive dopaminergic and noradrenergic stimulation: hyperthermia, tachycardia, stereotyped behavior, increased seizure susceptibility, and potential neurotoxicity at high doses.

Legal & Regulatory Status To Purchase 4F-MPH powder 2026

4F-MPH (4-Fluoromethylphenidate) is unscheduled in many jurisdictions when sold strictly for scientific research, analytical reference, forensic calibration, and educational purposes. However, it may be captured under analogue legislation, temporary class drug orders, or specific NPS controls depending on country/region. It is offered exclusively for legitimate laboratory research – not for human or veterinary consumption, diagnostic, therapeutic, or recreational use.

Buyers must independently confirm 4F-MPH legal status in their jurisdiction prior to ordering.

Frequently Asked Questions – 4F-MPH Research Chemical

What makes 4F-MPH different from methylphenidate? The para-fluoro substitution increases lipophilicity, potentially enhances DAT selectivity, and modifies metabolic clearance and duration of action.

How stable is 4F-MPH powder? Highly stable when stored cool, dry, and protected from light – typical shelf life 2–3 years under recommended conditions.

What solvents dissolve 4F-MPH best? Ethanol, methanol, DMSO, acidified water/saline – avoid strong bases.

Is 4F-MPH stronger than methylphenidate? In most transporter assays and behavioral models, 4F-MPH shows 3–5× greater potency at DAT and NET compared to methylphenidate.

Order your High purity 4F-MPH powder today – exclusively for scientific research, forensic, and analytical applications. Fast, discreet, tracked global delivery with full documentation.