3F-a-PVP

buy 3F-a-PVP online: Analytical Profile, Structure, and Research Overview

Introduction

Within modern analytical and forensic chemistry, 3F-a-PVP (3-Fluoro-α-pyrrolidinovalerophenone) stands as an important compound for structural comparison, chromatographic calibration, and analytical technique refinement.
As a fluorinated analog within the pyrrolidinophenone family, 3F-a-PVP has become relevant for research focusing on structure–activity relationships, fluorine substitution effects, and spectral differentiation of synthetic cathinone derivatives.

Analysts and chemists employ 3F-a-PVP as a reference material in laboratory investigations examining compound stability, fragmentation behavior, and identification protocols for complex sample matrices.

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1. Chemical Classification of 3F-a-PVP GC-MS analysis and Structure

3F-a-PVP belongs to the pyrrolidinophenone class of compounds, structurally related to α-PVP and other substituted cathinones. Its defining characteristic is the fluorine atom positioned on the aromatic ring, which significantly influences its electron distribution and chemical reactivity.

• IUPAC Name: 1-(3-Fluorophenyl)-2-(pyrrolidin-1-yl)-pentan-1-one

• Molecular Formula: C15H20FNO

• Molecular Weight: 249.32 g/mol

• Chemical Class: Pyrrolidinophenone derivative

• Functional Groups: Ketone, Aromatic Fluorine Substitution, Pyrrolidine Ring

The fluorine substitution increases molecular polarity, impacting chromatographic retention time and spectral signals observed in GC-MS and FT-IR analyses.

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2. Spectroscopic and 3F-a-PVP LC-MS identification

The identification of 3F-a-PVP relies on multi-instrumental analytical methods to ensure accuracy and reproducibility across research facilities.

a. Gas Chromatography–Mass Spectrometry (GC-MS)

GC-MS remains the primary technique for confirming the identity and purity of 3F-a-PVP.

• Its mass spectrum shows characteristic ion fragments resulting from cleavage around the pyrrolidine ring and carbonyl group.

• The fluoro-substitution produces distinctive isotopic patterns and retention indices, enabling clear differentiation from non-fluorinated analogs.

b. Fourier Transform Infrared Spectroscopy (FT-IR)

In FT-IR spectroscopy, 3F-a-PVP exhibits strong absorption in the 1000–1300 cm⁻¹ range, corresponding to C–F stretching vibrations. Additional peaks associated with C=O (ketone) and N–H bending confirm its structural composition.

c. Nuclear Magnetic Resonance (NMR) Spectroscopy

Both ¹H-NMR and ¹³C-NMR provide confirmation of the compound’s aromatic structure, pyrrolidine ring, and carbonyl carbon. Fluorine substitution introduces spin–spin coupling effects, visible in proton and carbon spectra, further supporting molecular identification.

d. High-Performance Liquid Chromatography (HPLC)

HPLC is employed for quantitative determination and purity assessment. Variations in mobile-phase polarity influence retention behavior, assisting in method optimization for similar cathinone analogs.

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3. Analytical Applications and Relevance in analytical chemistry research

3F-a-PVP’s distinct structure and spectral clarity make it valuable for comparative analytical research. Its main uses include:

• Reference calibration material in GC-MS or LC-MS spectral libraries.

• Method validation for forensic toxicology and trace detection workflows.

• Structure–Activity Relationship (SAR) studies to examine the influence of fluorine substitution on molecular behavior.

• Fragmentation pattern research, improving automated identification algorithms for substituted cathinones.

Its consistent analytical properties allow it to serve as a benchmark compound, enhancing the accuracy of chromatographic and spectrometric methods used across research facilities.

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4. Physicochemical Properties of fluorinated cathinone

Fluorination enhances 3F-a-PVP’s thermal stability, enabling consistent analytical measurements under controlled GC conditions.

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5. Comparison with Related Compounds in analytical chemistry research

Analytical studies often compare 3F-a-PVP with other α-PVP analogs, such as α-PVP, 4F-a-PVP, and 3,4-DM-α-PVP, to understand substitution effects.

This comparative data strengthens understanding of structure-dependent analytical behavior within the pyrrolidinophenone family.

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6. Research Applications in Analytical and Forensic Science

In forensic laboratories, 3F-a-PVP is used as a control material to verify detection sensitivity, test new analytical methods, and build spectral reference databases.

Its consistent analytical profile makes it ideal for:

• Chromatographic calibration

• Mass spectral library development

• Forensic toxicology training

• Analytical method validation

The reproducibility of its retention and ionization behavior ensures reliable comparison across studies, supporting accuracy in complex sample analysis.

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7. Data Interpretation and Method Validation

To buy 3F-a-PVP online contributes to data validation processes by providing measurable standards for:

• Retention time reproducibility in GC-MS and LC-MS systems

• Spectral fingerprint matching for unknown sample identification

• Method linearity and precision testing

By establishing robust reference points, it helps laboratories maintain analytical integrity and instrument calibration consistency.

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8. Safety, Handling, and Storage of fluorinated cathinone

Proper handling is essential for maintaining sample quality and ensuring safe research conditions.

• Storage: Keep in a cool, dry environment, away from light and moisture.

• Containment: Use airtight vials or containers with proper labeling.

• Handling: Follow local laboratory safety protocols, including PPE use.

• Documentation: Maintain accurate sample traceability records for research compliance.

Adhering to these guidelines ensures that the compound remains chemically stable and analytically reliable.

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9. Future Directions of 3F-a-PVP GC-MS analysis in Analytical Research

As analytical instrumentation continues to advance, 3F-a-PVP remains relevant for testing emerging mass spectrometry techniques and machine learning algorithms for automated compound recognition.

Future studies may explore:

• High-resolution MS for isomeric differentiation.

• AI-driven spectral deconvolution for complex mixtures.

• Multivariate data analysis (MVDA) in chromatography optimization.

• Cross-instrument reproducibility using hybrid GC×GC-MS or LC-MS/MS systems.

Such developments highlight the compound’s ongoing utility in forensic, environmental, and analytical chemistry research.

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10. Conclusion

3F-a-PVP (3-Fluoro-α-pyrrolidinovalerophenone) exemplifies the value of well-characterized analytical reference compounds in modern chemical science.
Its fluorine substitution enhances both chemical stability and spectral resolution, enabling more precise chromatographic separation, spectroscopic identification, and forensic classification.

By contributing to improved analytical accuracy and reproducibility, 3F-a-PVP supports advancements in forensic toxicology, method validation, and instrument calibration.
As analytical chemistry continues to evolve, such reference compounds remain integral to ensuring scientific reliability and innovation.