4-CL-PVP

buy 4-CL-PVP online: High-Purity 4-Chloro-α-Pyrrolidinopentiophenone Research Chemical | Lab-Tested (2026)

4-CL-PVP (4-Chloro-α-pyrrolidinopentiophenone), commonly abbreviated as 4-CL-PVP research chemical, 4-CL-PVP powder or 4-chloro-PVP, is a synthetic substituted cathinone belonging to the pyrrolidine-substituted α-pyrrolidinophenone (α-PVP) family. It features a chlorine atom at the para position of the phenyl ring, a structural modification that significantly influences lipophilicity, metabolic stability, monoamine transporter affinity, potency, and duration of action compared to the unsubstituted α-PVP or other para-halogenated analogs (4-F-α-PVP, 4-Br-PVP).

Since its first analytical detections in research chemical markets and seized drug samples around 2015–2017, 4-CL-PVP has become one of the most frequently monitored and requested synthetic cathinones in forensic toxicology, analytical chemistry, neuropharmacology, and structure-activity relationship (SAR) laboratories worldwide. Its continued presence in polydrug cases, driving-under-the-influence reports, overdose fatalities, and expanded NPS screening panels keeps demand high for high-purity reference material in 2026.

Every batch of 4-CL-PVP powder is supplied as a fine, white to off-white crystalline material with ≥98% purity, independently confirmed by third-party high-performance liquid chromatography (HPLC), liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF-MS), gas chromatography-mass spectrometry (GC-MS), and proton nuclear magnetic resonance (¹H-NMR). The product is vacuum-sealed in tamper-evident, moisture-resistant foil pouches or amber glass vials, accompanied by a current batch-specific Certificate of Analysis (COA), lot traceability, and explicit “Research Use Only – Not for Human Consumption” labeling.

4-CL-PVP for sale is offered exclusively for legitimate scientific research, analytical reference standard preparation, forensic method development/validation, toxicological profiling, monoamine transporter assays, and educational purposes. It is not intended, labeled, or sold for human or veterinary consumption, diagnostic use, therapeutic application, or any form of in-vivo experimentation outside approved research protocols.

Chemical & Physical Specifications – 4-CL-PVP Research Chemical

• Chemical Name: 1-(4-Chlorophenyl)-2-(pyrrolidin-1-yl)pentan-1-one
• IUPAC Name: 1-(4-Chlorophenyl)-2-pyrrolidin-1-ylpentan-1-one
• Synonyms: 4-CL-PVP, 4-Chloro-α-pyrrolidinopentiophenone, 4-chloro-PVP
• CAS Registry Number: 1400742-46-2 (freebase)
• Molecular Formula: C₁₅H₂₀ClNO
• Molecular Weight: 265.78 g/mol (freebase)
• Appearance: White to off-white fine crystalline powder
• Purity: ≥98.0% (third-party verified by HPLC, LC-QTOF-MS, GC-MS, ¹H-NMR)
• Form: Vacuum-sealed, tamper-evident packaging
• Solubility: Highly soluble in ethanol, methanol, DMSO, chloroform; moderately soluble in acidified water
• Storage Conditions: Cool (2–8 °C), dry, dark, airtight container – protect from light, heat, humidity & air exposure
• Shelf Life: Typically 24–36 months under recommended conditions

Why Laboratories & Researchers Choose Our 4-CL-PVP Powder

• Third-party HPLC, LC-QTOF-MS, GC-MS & NMR verified purity ≥98% – batch-specific COA included with every shipment
• Consistent batch-to-batch quality – essential for longitudinal studies, multi-site collaborations, method validation, calibration curves, and inter-laboratory reproducibility
• Accurate net weight & no fillers – precise, reproducible dosing with zero under- or over-dosing risk
• Superior handling properties – fine, low-static powder with excellent flowability and solubility in common analytical solvents
• Secure, discreet, tracked global shipping – plain packaging, chain-of-custody documentation available upon request
• Competitive bulk & institutional pricing – tailored volume discounts for universities, contract research organizations (CROs), forensic laboratories, government agencies & research consortia
• Research-use-only labeling & compliance support – clear documentation to support legitimate scientific intent and regulatory compliance audits

We understand the critical role high-purity reference materials play in analytical chemistry, forensic toxicology, and neuropharmacology — every 4-CL-PVP order is backed by that commitment.

Primary Research Applications of 4-CL-PVP (2026 Trends)

4-CL-PVP research chemical remains one of the most frequently monitored and requested synthetic cathinones in forensic, toxicological, and pharmacological laboratories worldwide due to its persistent detections in illicit markets, polydrug samples, driving-under-the-influence cases, overdose fatalities, and expanded NPS screening panels.

Key active research areas in 2026 include:

• Monoamine Transporter Activity & Selectivity 4-CL-PVP is a potent blocker and substrate-type releaser at dopamine (DAT) and norepinephrine (NET) transporters, with weaker activity at the serotonin transporter (SERT). This catecholamine-dominant profile makes 4-CL-PVP an excellent probe for studying DAT/NET-preferring stimulant mechanisms and comparing release vs reuptake inhibition ratios against α-PVP, MDPV, 3-MMC, 4F-α-PVP, and other pyrrolidine cathinones.
• Structure-Activity Relationship (SAR) Studies The para-chloro substitution increases lipophilicity and steric bulk compared to unsubstituted or alkyl-substituted cathinones, influencing potency, duration, selectivity, blood-brain barrier penetration, and metabolic fate. Researchers use 4-CL-PVP to map how halogen size and position modulate transporter affinity and behavioral outcomes.
• Metabolite Identification & Forensic Toxicology 4-CL-PVP undergoes extensive phase I metabolism (aromatic hydroxylation, N-dealkylation, β-keto reduction, and conjugation). Its primary metabolites are frequently detected in urine, blood, hair, and oral fluid in driving-under-the-influence, overdose, and postmortem cases. High-purity 4-CL-PVP powder is essential for synthesizing reference standards, validating LC-QTOF-MS and GC-MS/MS methods, and confirming identity in routine NPS screening panels.
• Behavioral Pharmacology & Locomotor Activity Rodent studies commonly employ 4-CL-PVP dosage ranges of 0.3–10 mg/kg i.p. or s.c. to evaluate locomotor stimulation, stereotypy, conditioned place preference, self-administration liability, and cross-sensitization with cocaine, methamphetamine, or MDPV.
• Analytical Method Development & Validation 4-CL-PVP is routinely included in expanded NPS/cathinone screening panels because it elutes close to α-PVP, 4F-α-PVP, 3-CMC, 4-CMC, and other pyrrolidine cathinones, requiring careful chromatographic separation and mass-spectral differentiation. It is also used to challenge the specificity of immunoassays and designer-drug screening tests.
• Pharmacokinetics & CYP450 Interaction Profiling The para-chloro group slows certain metabolic pathways compared to unsubstituted cathinones, offering researchers a tool to study differential CYP enzyme involvement (CYP2D6, CYP2B6) and potential drug-drug interactions.

Typical Research Dosage Ranges (Reference Only – 2026)

4-CL-PVP dosage varies significantly depending on the experimental model:

• Analytical calibration & reference standard preparation: 0.05–5 mg (standard curves, quality control)
• In-vitro transporter assays (DAT/NET/SERT): 0.1 nM – 10 μM (most active window: 30 nM – 3 μM)
• Rodent locomotor activity & behavioral pharmacology: 0.3–10 mg/kg i.p. or s.c. (dose-response curves common)
• High-dose neurochemical or toxicity modeling: 10–30 mg/kg (ethically restricted, IACUC-approved only)

Most published 4-CL-PVP research centers on the 1–10 mg/kg range in vivo and 30 nM – 3 μM concentrations in cellular/transporter assays, reflecting the compound’s high potency relative to non-halogenated cathinones.

Safety, Handling & Regulatory Notes – 4-CL-PVP Research Chemical

4-CL-PVP is a potent monoamine-releasing agent and reuptake inhibitor and must be handled only under controlled laboratory conditions:

• Work exclusively in a certified Class II biological safety cabinet or fume hood
• Wear appropriate PPE: nitrile gloves, lab coat, safety goggles, and respiratory protection
• Prevent skin contact, inhalation, and aerosol generation
• Dispose of all waste as hazardous chemical material per institutional and local regulations
• Store in amber glass vials, sealed, at 2–8 °C, protected from light, heat, humidity, and air exposure

4-CL-PVP side effects in research models are primarily related to excessive monoaminergic stimulation: hyperthermia, tachycardia, stereotyped behavior, increased seizure susceptibility, and potential neurotoxicity at high doses.

Legal status 2026: 4-CL-PVP is controlled or monitored in many jurisdictions under analogue acts, temporary class drug orders, or specific NPS legislation. It is sold exclusively for legitimate scientific research, analytical reference, forensic calibration, and educational purposes. Buyers must independently confirm 4-CL-PVP legal status in their jurisdiction prior to ordering.

Why Laboratories Consistently Choose Our 4-CL-PVP Powder

• Third-party HPLC, GC-MS & NMR verified purity ≥98% – batch-specific COA included with every shipment
• Consistent batch-to-batch quality – essential for longitudinal studies, multi-site collaborations, and method validation
• Accurate net weight & no fillers – precise, reproducible dosing with zero under- or over-dosing risk
• Superior handling properties – fine, non-static powder with excellent flowability and solubility in common research solvents
• Secure, discreet, tracked global shipping – plain packaging, chain-of-custody documentation available upon request
• Competitive bulk & institutional pricing – tailored volume discounts for universities, contract research organizations (CROs), forensic laboratories, and research consortia
• Research-use-only labeling & compliance support – clear documentation to support legitimate scientific intent and regulatory compliance audits

We understand the critical role high-purity reference materials play in analytical chemistry, forensic toxicology, and neuropharmacology — every 4-CL-PVP order is backed by that commitment.

Conclusion: Advance Cathinone & Stimulant Research with High-Purity 4-CL-PVP Powder

In 2026, 4-CL-PVP (4-Chloro-α-pyrrolidinopentiophenone) remains a cornerstone compound for laboratories investigating synthetic cathinone metabolism, monoamine transporter dynamics, novel NPS emergence, and comparative SAR within the para-halogenated pyrrolidine cathinone family. Its high purity, consistent quality, reliable supply, and precise handling characteristics make 4-CL-PVP powder an indispensable tool for rigorous forensic, toxicological, analytical, and pharmacological research.

Order your laboratory-grade 4-CL-PVP today – strictly for scientific research, analytical, and forensic applications. Fast, discreet, tracked global delivery with full documentation and batch traceability.