4-EMC Powder

buy 4-EMC online: High-Purity 4-Ethylmethcathinone Research Chemical Lab-Tested (2026)

4-EMC (4-Ethylmethcathinone), also widely known as 4-EMC research chemical, 4-ethylmethcathinone powder or 4-ethyl-N-methylcathinone, is a synthetic substituted cathinone belonging to the β-keto amphetamine family. It features an ethyl group at the para position of the phenyl ring and an N-methylated pyrrolidine-free amine chain, structurally positioning it between 4-MMC (mephedrone) and 4-EMC analogs such as 4-CMC and 3-CMC. This precise structural modification gives 4-EMC a distinct pharmacological and metabolic profile that has made it one of the most frequently requested cathinones in academic, forensic, toxicological and analytical chemistry laboratories worldwide since its first reported appearance in seized material around 2011–2012.

Every batch of 4-EMC powder supplied here is a fine, off-white to pale beige crystalline material with ≥98% purity, independently confirmed by third-party high-performance liquid chromatography (HPLC), gas chromatography-mass spectrometry (GC-MS) and proton nuclear magnetic resonance (¹H-NMR). The product is vacuum-sealed in tamper-evident, moisture-resistant foil pouches or amber glass vials to ensure long-term stability during storage and international transit. All orders include a current, batch-specific Certificate of Analysis (COA), lot traceability and clear “Research Use Only” labeling.

4-EMC for sale is offered strictly for legitimate scientific research, analytical reference standard preparation, forensic method development/validation, toxicological profiling and educational purposes — it is not intended, labeled, or sold for human or veterinary consumption, diagnostic use, therapeutic application or any form of in-vivo experimentation outside approved research protocols.

Chemical & Physical Specifications – 4-EMC Powder

• Chemical Name: 1-(4-Ethylphenyl)-2-(methylamino)propan-1-one
• Synonyms: 4-EMC, 4-Ethylmethcathinone, 4-ethyl-N-methylcathinone
• CAS Registry Number: 1395751-88-4 (freebase)
• Molecular Formula: C₁₂H₁₇NO
• Molecular Weight: 191.27 g/mol (freebase)
• Appearance: White to off-white fine crystalline powder
• Purity: ≥98.0% (third-party verified by HPLC, GC-MS, ¹H-NMR)
• Form: Vacuum-sealed, tamper-evident packaging
• Solubility: Highly soluble in ethanol, methanol, DMSO, chloroform; moderately soluble in acidified water/saline
• Storage Conditions: Cool (2–8 °C), dry, dark, airtight container – protect from light, heat, humidity & air exposure
• Shelf Life: Typically 24–36 months under recommended conditions

Why Laboratories & Researchers Choose Our 4-EMC Powder

• Third-party verified purity ≥98% – every batch ships with a detailed, current Certificate of Analysis showing HPLC chromatogram, GC-MS spectrum, and NMR confirmation
• Consistent batch-to-batch quality – essential for longitudinal studies, multi-site collaborations, method validation, calibration curves, and inter-laboratory reproducibility
• Accurate net weight & zero fillers – precise, reproducible dosing with no under- or over-dosing risk
• Superior handling properties – fine, low-static powder with excellent flowability and solubility in common analytical solvents
• Secure, discreet, tracked global shipping – plain packaging, chain-of-custody documentation available upon request
• Competitive bulk & institutional pricing – tailored volume discounts for universities, contract research organizations (CROs), forensic laboratories, government agencies & research consortia
• Research-use-only labeling & compliance support – clear documentation to support legitimate scientific intent and regulatory compliance audits

We understand the critical importance of reliable, high-purity reference materials in analytical chemistry, forensic toxicology, neuropharmacology, and drug-monitoring programs — every 4-EMC order is backed by that commitment.

Primary Research Applications of 4-EMC (2026 Trends)

4-EMC research chemical remains one of the most frequently requested substituted cathinones in academic, forensic, and contract laboratories due to its structural position in the ethyl-substituted cathinone series and its continuing detections in illicit markets, polydrug samples, and postmortem toxicology cases.

Key active research areas in 2026 include:

• Monoamine Transporter Activity & Selectivity 4-EMC acts as a potent blocker and substrate-type releaser at dopamine (DAT) and norepinephrine (NET) transporters, with weaker activity at the serotonin transporter (SERT). This catecholamine-dominant profile makes 4-EMC an excellent probe for studying DAT/NET-preferring stimulant mechanisms and comparing release vs reuptake inhibition ratios against mephedrone (4-MMC), flephedrone (4-FMC), 3-MMC, α-PVP, and MDPV.
• Structure-Activity Relationship (SAR) Studies The para-ethyl substitution increases lipophilicity and steric bulk compared to methyl-substituted cathinones, influencing potency, duration, selectivity, blood-brain barrier penetration, and metabolic fate. Researchers use 4-EMC to map how alkyl chain length at the para position modulates transporter affinity and behavioral outcomes.
• Metabolite Identification & Forensic Toxicology 4-EMC undergoes extensive phase I metabolism (N-demethylation, β-keto reduction, aromatic hydroxylation, and conjugation). Its primary metabolites are frequently detected in urine, blood, and hair in driving-under-the-influence, overdose, and postmortem cases. High-purity 4-EMC powder is essential for synthesizing reference standards, validating LC-QTOF-MS and GC-MS/MS methods, and confirming identity in routine NPS screening panels.
• Behavioral Pharmacology & Locomotor Activity Rodent studies commonly employ 4-EMC dosage ranges of 1–10 mg/kg i.p. or s.c. to evaluate locomotor stimulation, stereotypy, conditioned place preference, self-administration liability, and cross-sensitization with cocaine, methamphetamine, or MDPV.
• Analytical Method Development & Validation 4-EMC is routinely included in expanded NPS panels because it elutes close to other cathinones (mephedrone, 3-CMC, 4-CMC) and requires careful chromatographic separation and mass-spectral differentiation. It is also used to challenge the specificity of immunoassays and designer-drug screening tests.
• Pharmacokinetics & CYP450 Interaction Profiling The ethyl group slows certain metabolic pathways compared to methyl-substituted cathinones, offering researchers a tool to study differential CYP enzyme involvement (CYP2D6, CYP2B6) and potential drug-drug interactions.

Typical Research Dosage Ranges (Reference Only – 2026)

4-EMC dosage varies significantly depending on the experimental model:

• Analytical calibration & reference standard preparation: 0.05–5 mg (standard curves, quality control)
• In-vitro transporter assays (DAT/NET/SERT): 0.1 nM – 10 μM (most active window: 30 nM – 3 μM)
• Rodent locomotor activity & behavioral pharmacology: 1–10 mg/kg i.p. or s.c. (dose-response curves common)
• High-dose neurochemical or toxicity modeling: 10–30 mg/kg (ethically restricted, IACUC-approved only)

Most published 4-EMC research centers on the 1–10 mg/kg range in vivo and 30 nM – 3 μM concentrations in cellular/transporter assays, reflecting the compound’s moderate-to-high potency relative to non-substituted cathinones.

Safety, Handling & Regulatory Notes – 4-EMC Research Chemical

4-EMC is a potent monoamine-releasing agent and reuptake inhibitor and must be handled only under controlled laboratory conditions:

• Work exclusively in a certified Class II biological safety cabinet or fume hood
• Wear appropriate PPE: nitrile gloves, lab coat, safety goggles, and respiratory protection
• Prevent skin contact, inhalation, and aerosol generation
• Dispose of all waste as hazardous chemical material per institutional and local regulations
• Store in amber glass vials, sealed, at 2–8 °C, protected from light, heat, humidity, and air exposure

4-EMC side effects in research models are primarily related to excessive monoaminergic stimulation: hyperthermia, tachycardia, stereotyped behavior, increased seizure susceptibility, and potential neurotoxicity at high doses.

Legal status 2026: 4-EMC is controlled or monitored in many jurisdictions under analogue acts, temporary class drug orders, or specific NPS legislation. It is sold exclusively for legitimate scientific research, analytical reference, forensic calibration, and educational purposes. Buyers must independently confirm 4-EMC legal status in their jurisdiction prior to ordering.

Why Laboratories Consistently Choose Our 4-EMC Powder

• Third-party HPLC, GC-MS & NMR verified purity ≥98% – batch-specific COA included with every shipment
• Consistent batch-to-batch quality – essential for longitudinal studies, multi-site collaborations, and method validation
• Accurate net weight & no fillers – precise, reproducible dosing with zero under- or over-dosing risk
• Superior handling properties – fine, non-static powder with excellent flowability and solubility in common research solvents
• Secure, discreet, tracked global shipping – plain packaging, chain-of-custody documentation available upon request
• Competitive bulk & institutional pricing – tailored volume discounts for universities, contract research organizations (CROs), forensic laboratories, and research consortia
• Research-use-only labeling & compliance support – clear documentation to support legitimate scientific intent and regulatory compliance audits

We understand the critical role high-purity reference materials play in analytical chemistry, forensic toxicology, and neuropharmacology — every 4-EMC order is backed by that commitment.

Conclusion: Advance Cathinone & Stimulant Research with High-Purity 4-EMC Powder

In 2026, 4-EMC (4-Ethylmethcathinone) remains a cornerstone compound for laboratories investigating synthetic cathinone metabolism, monoamine transporter dynamics, novel NPS emergence, and comparative SAR within the alkyl-substituted cathinone family. Its high purity, consistent quality, reliable supply, and precise handling characteristics make 4-EMC powder an indispensable tool for rigorous forensic, toxicological, analytical, and pharmacological research.

Order your laboratory-grade 4-EMC today – strictly for scientific research, analytical, and forensic applications. Fast, discreet, tracked global delivery with full documentation and batch traceability.