Pagoclone PELLETS 10mg

buy Pagoclone 10mg pellets– Analytical Overview and Research Relevance

Introduction

Pagoclone is a cyclopyrrolone-based compound that has attracted increasing interest within analytical chemistry and neuropharmacological research. Its complex molecular framework and distinct receptor-binding profile make it a useful reference material for scientists studying GABAergic modulation, compound stability, and analytical characterization techniques.

The Pagoclone Pellet (10 mg) offers a controlled concentration suitable for laboratory calibration, chromatographic validation, and spectroscopic reference. This product page provides a detailed overview of Pagoclone’s molecular structure, analytical detection methods, and research relevance, serving as a technical reference for researchers in pharmacology, analytical chemistry, and forensic science.

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1. Chemical Identity and Structure of Pagoclone analytical research

Pagoclone belongs to the cyclopyrrolone class, structurally distinct yet functionally related to benzodiazepines.
Its chemical formula is C19H18ClN3O2, and it exhibits stereochemical complexity due to the chiral center within its pyrrolone ring system.

This molecular structure allows for hydrogen bonding, π–π stacking, and lipophilic interactions, which are essential features in ligand–receptor binding and analytical retention modeling.

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2. Analytical Chemistry and Characterization of Pagoclone chromatography

Pagoclone serves as a valuable compound for analytical method development, particularly in chromatography and spectroscopy.

a. GC-MS and LC-MS Analysis

When analyzed under Gas Chromatography–Mass Spectrometry (GC-MS) and Liquid Chromatography–Mass Spectrometry (LC-MS) conditions, Pagoclone exhibits:

• Distinct retention times due to its moderate polarity and aromatic core.

• Diagnostic fragmentation ions between m/z 230–310, reflecting its chlorophenyl and pyridazinone segments.

• A stable mass spectral fingerprint, making it suitable for library referencing in forensic or academic labs.

The LC-MS method often provides better resolution due to Pagoclone’s limited volatility, allowing for clear quantitative calibration curves and fragmentation pathway analysis.

b. FT-IR Spectroscopy

In Fourier-Transform Infrared (FT-IR) spectroscopy, Pagoclone demonstrates:

• C=O stretching vibrations at 1680–1700 cm⁻¹.

• Aromatic C–H stretches at 3000–3100 cm⁻¹.

• C–Cl absorption bands in the 700–800 cm⁻¹ region.

These spectral markers help in verifying compound purity and confirming identity through qualitative analytical assessment.

c. NMR Spectroscopy

¹H and ¹³C NMR spectra reveal unique chemical shift patterns attributable to the pyridazine and imidazopyridazine rings.
NMR provides critical insight into molecular conformation and substituent orientation, important for pharmacological and computational modeling.

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3. Chromatographic Behavior and Pagoclone spectroscopy

In High-Performance Liquid Chromatography (HPLC), Pagoclone’s retention is influenced by:

• Its moderate lipophilicity (logP ≈ 3.5)

• Aromatic stacking within stationary phases

• pH-dependent ionization of the nitrogen atoms in its ring system

Mobile phase optimization using acetonitrile–water gradients (pH 3–4) enhances peak symmetry and reproducibility.

These chromatographic features make Pagoclone suitable as a reference standard for method validation and multi-analyte comparison studies.

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4. Pharmacological and Receptor Research Background

Although Pagoclone is structurally distinct from classical benzodiazepines, it functions as a partial agonist at the GABA_A receptor complex.
Its interaction with GABAergic pathways has been explored for its potential anxiolytic and anticonvulsant properties in experimental settings.

Receptor Binding Profile

These studies highlight Pagoclone’s role in receptor pharmacodynamics and ligand efficiency modeling, relevant for computational drug discovery and SAR (Structure–Activity Relationship) analysis.

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5. Applications of Pagoclone analytical research in Chemistry

Pagoclone’s unique structure and stable physical properties make it valuable for:

• Spectroscopic calibration – ideal for validating IR, UV-Vis, and MS detection systems.

• Chromatographic performance testing – determining reproducibility across stationary phases.

• Forensic reference libraries – adding spectral and chromatographic data to controlled reference sets.

• Quantitative validation – using known purity standards for mass accuracy correction.

Its distinctive chlorine isotope pattern also aids in mass spectral identification, helping laboratories improve detection algorithms for halogenated compounds.

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6. Data Integrity and Method Validation of Cyclopyrrolone structure

Accurate research requires data reproducibility, traceability, and method integrity.
Pagoclone serves as a benchmark standard for:

• Testing instrument calibration stability

• Evaluating mass fragmentation repeatability

• Cross-validating analytical results between GC-MS and LC-MS systems

Such validation is critical for regulatory compliance, academic publications, and chemical database accuracy.

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7. Storage and Handling Recommendations to buy Pagoclone 10mg pellets

To ensure long-term stability:

• Storage temperature: 2–8°C in a sealed, desiccated container

• Protection: Avoid direct light and moisture

• Handling: Apply laboratory-standard PPE and minimize air exposure

• Documentation: Maintain proper record of lot numbers and reference codes

These guidelines help preserve analytical fidelity and ensure consistent spectral and chromatographic results over time.

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8. Research Significance and Future Directions To buy Pagoclone 10mg pellets

Pagoclone continues to draw academic interest in GABAergic pharmacology and analytical detection sciences. Future research directions include:

• High-resolution mass spectrometry (HRMS) profiling to map minor fragmentation pathways.

• Computational modeling of receptor-ligand interactions.

• Cross-method validation across different chromatography systems.

• Machine-learning classification of benzodiazepine analog spectra.

These studies contribute to the growing field of AI-assisted forensic identification and analytical chemistry data curation.

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9. Summary of Analytical Characteristics and Cyclopyrrolone structure

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Conclusion

The Pagoclone 10mg Pellet stands as a scientifically valuable compound for analytical chemistry and receptor research.
Its balanced physicochemical profile, defined molecular identity, and reproducible analytical characteristics make it a key reference standard for forensic, academic, and pharmacological laboratories.

To buy Pagoclone 10mg pellets and studying through spectroscopic and chromatographic methods, researchers can deepen understanding of cyclopyrrolone analogs, GABAergic activity, and compound identification strategies in analytical chemistry.